Clinical Study Abstracts

Is low magnesium concentration a risk factor for coronary heart disease? The Atherosclerosis Risk in Communities (ARIC) Study
Fangzi Liao, MD, Aaron R. Folsom, MD, Frederick L. Brancati, MD. (Am Heart J 1998;136:480-90.) Copyright © 1998 by Mosby, Inc.

Background: Hypomagnesemia has been hypothesized to play a role in coronary heart disease (CHD), but few prospective epidemiologic studies have been conducted.

Methods and Results: We examined the relation of serum and dietary magnesium with CHD incidence in a sample of middle-aged adults (n = 13,922 free of baseline CHD) from 4 US communities. Over 4 to 7 years of follow-up, 223 men and 96 women had CHD develop. After adjustment for sociodemographic characteristics, waist/hip ratio, smoking, alcohol consumption, sports participation, use of diuretics, fibrinogen, total and high-density lipoprotein cholesterol levels, triglyceride levels, and hormone replacement therapy, the relative risk of CHD across quartiles of serum magnesium was 1.00, 0.92, 0.48, and 0.44 (P for trend = 0.009) among women and 1.00, 1.32, 0.95, and 0.73 (P for trend = 0.07) among men. The adjusted relative risk of CHD for the highest versus the lowest quartile of dietary magnesium was 0.69 in men (95% confidence interval 0.45 to 1.05) and 1.32 in women (0.68 to 2.55).

Conclusions: These findings suggest that low magnesium concentration may contribute to the pathogenesis of coronary atherosclerosis or acute thrombosis. Get Complete Article

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